Symptom Management Drugs for MS

Symptom Management Drugs

Source: Sussex MS Centre Newsletter – Winter 2017 Issue 79


Below are some drugs that may help with your MS symptoms.  Always speak to your consultant and MS Nurse about symptoms that are worrying you.  There may well be a drug that will help.  This is not an exhaustive list of all the drugs that are prescribed to provide symptom relief, but many of the below are prescribed to people with MS.

Alprostadil (Caverject) Erectile dysfunction
Amantadine (Symmetrel) May lessen fatigue
Amitriptyline (Triptafen)
Baclofen (Lioresal) To relieve spasticity and spasm
Baclofen pump For severed spasm. Pump is implanted.
Botulinum toxin (Botox) To relieve spasticity and spasm and bladder symptoms
Carbamazepine (Tegretol) To treat pain associated with spasticity and spasms, trigeminal neuralgia and some other pain symptoms.
Cialis (Tadalafil) Erectile dysfunction
Clonazepam (Rivotril) Tremor


Dantrolene sodium (Dantrium) Chronic, severe spasticity and spasms
Desmopressin (Desmotabs) Bladder problems
Diazepam (Valium) Spasticity and spasm. Severe anxiety.
Fampridine (Fampyra) Can improve walking. Rarely available on the NHS.
Fluoxetine (Prozac) Depression.  Some research findings suggest it reduces the inflammation around nerves in MS.
Gabapentin Neuropathic pain such as trigeminal neuralgia or abnormal sensations (dysaesthesia), such as burning or pins and needles.
Imipramine (Tofranil) Antidepressant which sometimes helps relieve pain and pins and needles.
Modafinil (Provigil) Fatigue.  Not currently recommended for use for MS fatigue.
Nuedexta Pseudobulbar effect – uncontrolled laughing or crying
Oxbutynin (Ditropan) Bladder urgency
Paroxetine (Seroxat) Depression and anxiety
Phenol Severe spasticity where other treatment options have proven ineffective
Phenytoin (Epanutin) Trigeminal neuralgia or other painful sensations (dysaesthesia) if other approaches have not worked.
Pregablin (Lyrica) Neuropathic or nerve pain
Sativex (nabiximols) Spasticity
Steroids (methylprednisolone) Sometimes used to aid recover after relapse.


Tizanidine (Zanalfex) Spasticity
Tolterodine (Detrusitol) Bladder Problems
Vardenafil (Levitra) Erectile dysfunction
Viagra (sildenafil citrate) Erectile dysfunction


If you have an experience of any of the drugs which may help others please do let us know.